Scope and mechanism of the highly stereoselective metal-mediated domino aldol reactions of enolates with aldehydes

• M. Emin Cinar,
• Bernward Engelen,
• Martin Panthöfer,
• Hans-Jörg Deiseroth,
• Jens Schlirf and
• Michael Schmittel

Beilstein J. Org. Chem. 2016, 12, 813–824, doi:10.3762/bjoc.12.80

• aldehydes in the presence of metal halides to furnish tetrahydro-2H-pyran-2,4-diols in a highly diastereoselective manner, is investigated thoroughly by experiments and computations. The reaction was also successfully implemented on a flow micro reactor system. Keywords: DFT; diastereoselective reaction

Synthesis and immunological evaluation of protein conjugates of Neisseria meningitidis X capsular polysaccharide fragments

• Laura Morelli,
• Damiano Cancogni,
• Marta Tontini,
• Alberto Nilo,
• Sara Filippini,
• Paolo Costantino,
• Maria Rosaria Romano,
• Francesco Berti,
• Roberto Adamo and
• Luigi Lay

Beilstein J. Org. Chem. 2014, 10, 2367–2376, doi:10.3762/bjoc.10.247

• -phosphonates [25]. An additional improvement in α-H-phosphonate 7 formation was achieved by carrying out the reaction under microfluidic conditions. The Micro Reactor Technology (MRT) is gaining increasing attention for drug discovery. Some of its various possible advantages when compared to more conventional

Continuous flow nitration in miniaturized devices

• Amol A. Kulkarni

Beilstein J. Org. Chem. 2014, 10, 405–424, doi:10.3762/bjoc.10.38

• be overlooked without focusing entirely on using the “micro reactor” concept. 3.1.4 Nitration with solid acid catalysts. The continuous flow vapour phase nitration using a solid acid catalyst has also been explored [26]. It is known that the solid acid catalysts, i.e., ZSM and other zeolite catalysts

Photochemistry with laser radiation in condensed phase using miniaturized photoreactors

• Elke Bremus-Köbberling,
• Arnold Gillner,
• Frank Avemaria,
• Céline Réthoré and
• Stefan Bräse

Beilstein J. Org. Chem. 2012, 8, 1213–1218, doi:10.3762/bjoc.8.135

• . Keywords: azides; chemical diversity; flow chemistry; heterocycles; laser; micro reactor; Introduction Classical combinatorial chemistry [1][2] approaches usually aim at the synthesis of multi-milligram amounts of new compounds to extend screening decks used in multiple screening campaigns [3]. An

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor

• Bernhard Gutmann,
• Toma N. Glasnov,
• Tahseen Razzaq,
• Walter Goessler,
• Dominique M. Roberge and
• C. Oliver Kappe

Beilstein J. Org. Chem. 2011, 7, 503–517, doi:10.3762/bjoc.7.59

• material and/or surface phenomena resulting from the high surface-to-volume ratio in a micro-reactor environment. Since, in most cases, microreactors or related flow devices (coils, tubular reactors) for high-temperature/high-pressure applications are made out of non-transparent materials (i.e., stainless

From discovery to production: Scale- out of continuous flow meso reactors

• Peter Styring and
• Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

• the reagent solution flowed using a syringe pump [8][9][13]. This is termed as meso reactor as it shows many of the benefits of a micro reactor but at a slightly larger volume. Using a mesoporous version of the catalyst the rate of reaction was enhanced over 3000 times which meant that useful

The development and evaluation of a continuous flow process for the lipase- mediated oxidation of alkenes

• Charlotte Wiles,
• Marcus J. Hammond and
• Paul Watts

Beilstein J. Org. Chem. 2009, 5, No. 27, doi:10.3762/bjoc.5.27

• ; hydrogen peroxide; lipase; micro reactor; Novozym® 435; peracids; Introduction In addition to their synthetic value as intermediates in the preparation of diols, alcohols, hydroxyesters and alkenes, epoxides are a key raw material in many industrial processes, finding application in adhesives, polymers

• ) was selected as a model reaction (Scheme 3) for investigation within the reaction set-up illustrated in Figure 1. Micro reactor set-up As Figure 1 depicts, the flow reactor consisted of a borosilicate glass capillary (3.0 mm (i.d.) × 3.6 cm (long) packed with 100 mg of Novozym® 435 (4), with reactions

• of 5.0 × 10−2 M the next step of the investigation was aimed at evaluating the enzyme’s tolerance to H2O2 (2) in the micro reactor. To achieve this, the concentration of alkene 6 was maintained at 0.1 M and the oxidant 2 concentration varied between 5 × 10−2 and 0.3 M (0.5 to 3.0 equiv with respect

Themed series in organo- fluorine chemistry

• David O'Hagan

Beilstein J. Org. Chem. 2008, 4, No. 11, doi:10.3762/bjoc.4.11

• /Deoxofluor, HF:amine reagents and TBAF have secured a central role in the armory of organic chemists and the ready availability and improvements in their formulations are allowing these reagents to be incorporated beyond the research lab and into process development. Indeed micro-reactor technology is